蛋白质 - 热量营养不良对大鼠地塞米松药代动力学、胎盘转运及组织定位的影响。
Influence of protein-calorie malnutrition on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats.
作者信息
Varma D R, Yue T L
出版信息
Br J Pharmacol. 1984 Sep;83(1):131-7. doi: 10.1111/j.1476-5381.1984.tb10127.x.
Abstract
The influence of protein-calorie malnutrition (PCM) on the pharmacokinetics, transplacental passage and tissue localization of dexamethasone was determined in Sprague-Dawley rats. PCM increased the plasma half-life and volume of distribution of dexamethasone in pregnant but not in nonpregnant rats. Ratios of foetal to maternal serum dexamethasone concentrations were 0.2-0.4 at different dose levels (0.8-20 mumol kg-1), time intervals (0.25-12 h) and gestational ages (day 14-21). PCM increased the foetal serum and tissue concentrations of dexamethasone but exerted no significant effect on its binding to maternal and foetal serum proteins or on its metabolism by the placenta. It is suggested that significantly lower foetal than maternal serum levels of dexamethasone are due to efficient elimination of this agent by the foeto-placental unit and an impairment of this mechanism may account for the observed increase in dexamethasone levels in the foetuses of PCM rats.
摘要
在斯普拉格-道利大鼠中测定了蛋白质-热量营养不良（PCM）对地塞米松的药代动力学、经胎盘转运及组织定位的影响。PCM增加了地塞米松在妊娠大鼠而非未妊娠大鼠中的血浆半衰期和分布容积。在不同剂量水平（0.8 - 20 μmol kg⁻¹）、时间间隔（0.25 - 12小时）及胎龄（第14 - 21天）时，胎儿与母体血清地塞米松浓度之比为0.2 - 0.4。PCM增加了地塞米松在胎儿血清及组织中的浓度，但对其与母体和胎儿血清蛋白的结合或胎盘对其代谢均无显著影响。提示胎儿血清地塞米松水平显著低于母体血清水平是由于胎儿-胎盘单位对该药物的有效清除，而这种机制的损害可能是PCM大鼠胎儿中地塞米松水平升高的原因。
相似文献
1
Influence of protein-calorie malnutrition on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats.蛋白质 - 热量营养不良对大鼠地塞米松药代动力学、胎盘转运及组织定位的影响。
Br J Pharmacol. 1984 Sep;83(1):131-7. doi: 10.1111/j.1476-5381.1984.tb10127.x.
2
Influence of streptozotocin-diabetes on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats.链脲佐菌素诱导的糖尿病对大鼠地塞米松药代动力学、胎盘转运及组织定位的影响。
Br J Pharmacol. 1984 Sep;83(1):139-44. doi: 10.1111/j.1476-5381.1984.tb10128.x.
3
The influence of maternal protein deficiency on the placental transfer of salicylate in rats.母体蛋白质缺乏对大鼠水杨酸盐胎盘转运的影响。
Br J Pharmacol. 1983 Jan;78(1):233-8. doi: 10.1111/j.1476-5381.1983.tb09384.x.
4
Influence of age, sex, pregnancy and protein-calorie malnutrition on the pharmacokinetics of salicylate in rats.年龄、性别、妊娠及蛋白质-热量营养不良对大鼠水杨酸盐药代动力学的影响。
Br J Pharmacol. 1984 May;82(1):241-8. doi: 10.1111/j.1476-5381.1984.tb16464.x.
5
Maternal malnutrition and placental transfer of alpha-aminoisobutyric acid in the rat.大鼠母体营养不良与α-氨基异丁酸的胎盘转运
Science. 1975 Feb 21;187(4177):648-50. doi: 10.1126/science.803709.
6
Investigation of the maternal to foetal serum concentration gradient of dexamethasone in the rat.大鼠体内地塞米松母体与胎儿血清浓度梯度的研究。
Br J Pharmacol. 1986 Aug;88(4):815-20. doi: 10.1111/j.1476-5381.1986.tb16254.x.
7
Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids.妊娠大鼠中瘦素的分布与代谢：妊娠晚期经胎盘的瘦素转运增加，但过量糖皮质激素会使其减少。
Endocrinology. 2003 Jul;144(7):3024-30. doi: 10.1210/en.2003-0145.
8
Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition.呋塞米在蛋白质 - 热量营养不良中的药代动力学和药效学
J Pharmacokinet Biopharm. 1993 Feb;21(1):1-17. doi: 10.1007/BF01061772.
9
Placental hormones, nutrition, and fetal development.胎盘激素、营养与胎儿发育。
Fed Proc. 1980 Feb;39(2):261-5.
10
Effects of cysteine on the pharmacokinetics of intravenous phenytoin in rats with protein-calorie malnutrition.半胱氨酸对蛋白质-热量营养不良大鼠静脉注射苯妥英钠药代动力学的影响。
Int J Pharm. 2001 Oct 23;229(1-2):45-55. doi: 10.1016/s0378-5173(01)00815-8.
引用本文的文献
1
[Influence of dexamethasone on the cell polarity and PAR complex of the embryonic epithelial cells in the palate].[地塞米松对腭部胚胎上皮细胞极性及PAR复合体的影响]
Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Feb 1;36(1):9-16. doi: 10.7518/hxkq.2018.01.003.
2
A mechanism-based pharmacokinetic/pharmacodynamic model for CYP3A1/2 induction by dexamethasone in rats.一种基于机制的大鼠 CYP3A1/2 诱导剂地塞米松的药代动力学/药效学模型。
Acta Pharmacol Sin. 2012 Jan;33(1):127-36. doi: 10.1038/aps.2011.161.
3
Stability of dexamethasone sodium phosphate in rat plasma.地塞米松磷酸钠在大鼠血浆中的稳定性
Int J Pharm. 2005 Sep 14;301(1-2):262-6. doi: 10.1016/j.ijpharm.2005.06.003.
4
Comparison of dexamethasone pharmacokinetics in female rats after intravenous and intramuscular administration.雌性大鼠静脉注射和肌肉注射地塞米松后的药代动力学比较。
Biopharm Drug Dispos. 2005 Apr;26(3):85-91. doi: 10.1002/bdd.435.
5
Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats.孕期药代动力学的面积/矩和房室模型：在绵羊和大鼠母体/胎儿接触皮质类固醇中的应用
Pharm Res. 2004 Dec;21(12):2279-92. doi: 10.1007/s11095-004-7681-7.
6
In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery.聚（L-天冬氨酸）作为结肠特异性给药药物载体的体内药代动力学研究，用于评估其作为药物载体的性能。
J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. doi: 10.1007/BF02353640.
7
Influence of streptozotocin-diabetes on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats.链脲佐菌素诱导的糖尿病对大鼠地塞米松药代动力学、胎盘转运及组织定位的影响。
Br J Pharmacol. 1984 Sep;83(1):139-44. doi: 10.1111/j.1476-5381.1984.tb10128.x.
8
Investigation of the maternal to foetal serum concentration gradient of dexamethasone in the rat.大鼠体内地塞米松母体与胎儿血清浓度梯度的研究。
Br J Pharmacol. 1986 Aug;88(4):815-20. doi: 10.1111/j.1476-5381.1986.tb16254.x.
9
Nonspecific action of glucocorticosteroids after high-dose pulse therapy?大剂量脉冲疗法后糖皮质激素的非特异性作用？
Agents Actions. 1990 Aug;31(1-2):148-51. doi: 10.1007/BF02003235.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The experimental production of cleft palate with cortisone and other hormones.用可的松及其他激素进行腭裂的实验性诱导
J Cell Physiol Suppl. 1954 May;43(Suppl. 1):237-59. doi: 10.1002/jcp.1030430411.
3
Drug disposition and pharmacokinetics in the maternal-placental-fetal unit.药物在母-胎-胎盘单位中的处置与药代动力学。
Pharmacol Ther. 1980;10(2):301-28. doi: 10.1016/0163-7258(80)90085-6.
4
Anti-inflammatory and ulcerogenic effects and pharmacokinetics of dexamethasone in protein-deficient rats.地塞米松在蛋白质缺乏大鼠体内的抗炎、致溃疡作用及药代动力学
J Pharmacol Exp Ther. 1980 Jul;214(1):197-202.
5
Comparison of the transplacental pharmacokinetics of cortisol and triamcinolone acetonide in the rhesus monkey.恒河猴中皮质醇和曲安奈德的经胎盘药代动力学比较。
J Pharmacol Exp Ther. 1982 Nov;223(2):368-74.
6
Influence of protein deficiency in rats on hormonal status and cytoplasmic glucocorticoid receptors in maternal and fetal tissues.蛋白质缺乏对大鼠母体和胎儿组织中激素状态及细胞质糖皮质激素受体的影响。
J Endocrinol. 1982 Oct;95(1):49-58. doi: 10.1677/joe.0.0950049.
7
Pharmacokinetics in the ovine maternal-fetal unit.绵羊母胎单位的药代动力学。
Annu Rev Pharmacol Toxicol. 1982;22:221-43. doi: 10.1146/annurev.pa.22.040182.001253.
8
The influence of maternal protein deficiency on the placental transfer of salicylate in rats.母体蛋白质缺乏对大鼠水杨酸盐胎盘转运的影响。
Br J Pharmacol. 1983 Jan;78(1):233-8. doi: 10.1111/j.1476-5381.1983.tb09384.x.
9
Determination of plasma dexamethasone in the mother and the newborn after administration of the hormone in a clinical trial.在一项临床试验中，对给予激素后的母亲和新生儿血浆地塞米松进行测定。
J Clin Endocrinol Metab. 1983 Jan;56(1):127-33. doi: 10.1210/jcem-56-1-127.
10
Pharmacological significance of changes in glucocorticoid receptors in protein-deficient young and adult rats of both sexes and pregnant rats.蛋白质缺乏的幼年和成年雌雄大鼠及妊娠大鼠中糖皮质激素受体变化的药理学意义。
J Pharmacol Exp Ther. 1982 Dec;223(3):816-23.
Zotero 插件