使用多巴胺激动剂治疗垂体瘤期间的精神反应。
Psychotic reactions during treatment of pituitary tumours with dopamine agonists.
作者信息
Turner T H, Cookson J C, Wass J A, Drury P L, Price P A, Besser G M
出版信息
Br Med J (Clin Res Ed). 1984 Oct 27;289(6452):1101-3. doi: 10.1136/bmj.289.6452.1101.
Abstract
Of 600 patients treated with the dopamine agonist drugs bromocriptine and lisuride for functioning pituitary tumours, eight developed drug related psychoses. Symptoms included auditory hallucinations, delusional ideas, and appreciable changes in mood. These reactions occurred with lower doses of the drugs than previously reported and remitted when treatment was stopped. The possibility of psychiatric side effects with dopamine agonist treatment should be recognised in view of the strain that may be placed on patients and their families.
摘要
在600例使用多巴胺激动剂药物溴隐亭和麦角乙脲治疗功能性垂体瘤的患者中，有8例出现了与药物相关的精神病。症状包括幻听、妄想观念和明显的情绪变化。这些反应在比以前报道的更低剂量的药物时就出现了，并且在停药后症状缓解。鉴于可能给患者及其家庭带来的压力，应认识到多巴胺激动剂治疗出现精神副作用的可能性。
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