Polu J M, Puchelle E, Sadoul P
Nouv Presse Med. 1978 Feb 18;7(7):557-63.
Having summarised recent studies of the biochemical and rheological nature of bronchial secretions, the authors envisage different types of drugs which modify bronchial secretions: mucolytic agents, drugs modifying local water equilibrium and mucoregulators. According to the modes of action of these drugs and the nature of the secretory disturbances, the authors propose new therapeutic schemes. The treatment of chronic bronchial hypersecretion should not necessarily aim to fluidify the secretions but should normalize their rheological properties in order to improve mucociliary transport. The various fluidifiers and regulators of bronchial secretions are in no way interchangeable and should only be used when appropriate.
在总结了近期关于支气管分泌物的生化和流变学性质的研究后，作者设想了不同类型的可改变支气管分泌物的药物：黏液溶解剂、改变局部水平衡的药物和黏液调节剂。根据这些药物的作用方式和分泌紊乱的性质，作者提出了新的治疗方案。慢性支气管分泌过多的治疗不一定旨在使分泌物液化，而应使其流变学性质正常化，以改善黏液纤毛运输。各种支气管分泌物的液化剂和调节剂绝不可相互替代，仅应在适当的时候使用。
