Puchelle E, Girard F, Zahm J M
Bull Eur Physiopathol Respir. 1976 Nov-Dec;12(6):771-9.
Optimal relationships between mucociliary clearance and rheological properties of bronchial secretions expectorated by patients with chronic bronchitis have been analysed by successive measurements of visco-elasticity with a rotational rheometer and of transport velocity on frog palate mucosa. It appears that the role of the elastic component is predominent. Sputum characterized by very low strain recovery (SR less than 4 units) or conversely by very high elasticity (SR greater than 20 units) is transported at a low rate in comparison to that of the control frog mucus (relative transport rate less than 0.5). Pronounced hyperviscosity of sputum (no greater than 200 poises) appears also as a limiting factor to the mucociliary transport. The best transported secretions (relative transport rate greater than 0.7) are characterized by a relative elasticity (SR) of 4 to 13 units and a viscosity (no) of 25 to 200 poises. Under the action of mucolytic agents such as N-acetylcysteine, sputum initially characterized by low strain recovery (SR less than 4 units) is transported at a much slower rate which is related to the increased loss of elasticity. These results indicate that mucolytic drugs must be administered with great care in patients with chronic bronchitis. Moreover, they should not be used in patients with very low visco-elastic secretions which reflect the non-functional state of the bronchial mucosa.
通过用旋转流变仪连续测量粘弹性以及在蛙腭黏膜上测量传输速度，分析了慢性支气管炎患者咳出的支气管分泌物的黏液纤毛清除与流变学特性之间的最佳关系。结果表明，弹性成分起主要作用。与对照蛙黏液相比，应变恢复率极低（SR小于4个单位）或相反弹性极高（SR大于20个单位）的痰液传输速率较低（相对传输速率小于0.5）。痰液明显的高粘度（不大于200泊）也似乎是黏液纤毛传输的限制因素。传输最佳的分泌物（相对传输速率大于0.7）的特征是相对弹性（SR）为4至13个单位，粘度（ηo）为25至200泊。在N-乙酰半胱氨酸等黏液溶解剂的作用下，最初应变恢复率低（SR小于4个单位）的痰液传输速度要慢得多，这与弹性损失增加有关。这些结果表明，黏液溶解药物在慢性支气管炎患者中必须谨慎使用。此外，它们不应在反映支气管黏膜无功能状态的粘弹性分泌物极低的患者中使用。
