Vierhapper H, Jörg J, Waldhäusl W
Clin Sci (Lond). 1984 Dec;67(6):579-83. doi: 10.1042/cs0670579.
The effect of acetylsalicylic acid (ASA, 3 g/day for 3 days) and of indomethacin (IND, 150 mg/day for 3 days) on diuresis and on the excretion of prostaglandin E2 (PGE2) was studied in six healthy, male volunteers. After overnight deprivation the subjects received an oral water load (20 ml/kg) and hourly urine volumes were replaced by an equivalent volume of water by mouth for 4 h. Pretreatment with both ASA and IND induced a comparable suppression (P less than 0.05 to less than 0.001) in the excretion of PGE2, but only IND also reduced (P less than 0.05) diuresis, free water clearance and the excretion of sodium. The excretion of creatinine was uninfluenced by both ASA and IND. These data indicate that a mechanism other than cyclo-oxygenase inhibition is involved in the effect of IND and ASA on diuresis in man.
研究了乙酰水杨酸（ASA，3克/天，共3天）和吲哚美辛（IND，150毫克/天，共3天）对6名健康男性志愿者利尿作用及前列腺素E2（PGE2）排泄的影响。在经过一夜禁水后，受试者口服水负荷（20毫升/千克），并在4小时内每小时经口补充等量的水以替代尿量。ASA和IND预处理均导致PGE2排泄受到类似程度的抑制（P小于0.05至小于0.001），但只有IND还降低了（P小于0.05）利尿、自由水清除率和钠排泄。肌酐排泄不受ASA和IND的影响。这些数据表明，IND和ASA对人体利尿作用的影响涉及环氧化酶抑制以外的机制。
