Dixey J J, Williams T D, Lightman S L, Lant A F, Brewerton D A
Clin Sci (Lond). 1986 May;70(5):409-16. doi: 10.1042/cs0700409.
The renal response to graded intravenous infusions of arginine vasopressin (AVP) was investigated in a two part study in six volunteers. First, under maximal water diuresis, seven control incremental infusions of AVP were given from zero to 12 fmol min-1 kg-1. Second, the AVP infusions were repeated after pretreatment with indomethacin, 150 mg daily for 36 h. After the AVP infusions, plasma AVP concentrations did not change significantly and remained within the physiological range; in contrast, urinary AVP excretion rate increased steadily. Indomethacin did not alter the plasma or urinary concentrations of AVP. AVP caused a fall in urine flow rate from a state of maximal diuresis to one of maximal antidiuresis. After indomethacin, fractional free water clearance was reduced by an average of 26% at the zero, 2 and 4 fmol min-1 kg-1 infusion rates of AVP. A significant increase in fractional sodium clearance of approximately 50% occurred during the AVP infusions, which was abolished after pretreatment with indomethacin. After indomethacin, urinary prostaglandin E2 (PGE2) excretion rate was reduced by an average of 40% at the zero and 2 fmol min-1 kg-1 infusion rates of AVP. At higher AVP infusion rates, no significant inhibition of PGE2 was observed. Urinary kallikrein excretion rate decreased steadily to one-third of its original value after AVP and this change remained unaltered by indomethacin. The findings show that infusions of AVP, resulting in plasma concentrations in the physiological range, evoke a maximal antidiuretic response, which is accompanied by natriuresis.(ABSTRACT TRUNCATED AT 250 WORDS)
在一项针对6名志愿者的两部分研究中，研究了肾脏对精氨酸加压素（AVP）分级静脉输注的反应。首先，在最大水利尿状态下，从0至12 fmol min⁻¹ kg⁻¹进行了7次AVP对照递增输注。其次，在每天服用150 mg吲哚美辛预处理36小时后，重复进行AVP输注。AVP输注后，血浆AVP浓度无显著变化，仍处于生理范围内；相反，尿AVP排泄率稳步增加。吲哚美辛未改变AVP的血浆或尿浓度。AVP使尿流率从最大利尿状态降至最大抗利尿状态。使用吲哚美辛后，在AVP输注速率为0、2和4 fmol min⁻¹ kg⁻¹时，自由水清除率平均降低了26%。在AVP输注期间，钠清除率分数显著增加约50%，在使用吲哚美辛预处理后这种增加被消除。使用吲哚美辛后，在AVP输注速率为0和2 fmol min⁻¹ kg⁻¹时，尿前列腺素E2（PGE2）排泄率平均降低了40%。在更高的AVP输注速率下，未观察到对PGE2的显著抑制作用。AVP后尿激肽释放酶排泄率稳步降至其原始值的三分之一，且这种变化未被吲哚美辛改变。研究结果表明，输注导致血浆浓度处于生理范围内的AVP会引发最大抗利尿反应，并伴有利钠作用。（摘要截短至250字）
