金属螯合剂对必需微量元素排泄及组织水平的影响。

Effect of metal chelators on excretion and tissue levels of essential trace elements.

作者信息

Tandon S K, Jain V K, Mathur A K

出版信息

Environ Res. 1984 Oct;35(1):237-45. doi: 10.1016/0013-9351(84)90132-4.

Abstract

The influence of one, three, and six doses of ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), and triethylenetetramine (TETA) on the urinary excretion of Ca, Cu, Fe, and Zn, and on their levels in liver, kidneys, heart, and serum in rats, was investigated to ascertain their suitability in amelioration of metal intoxication. While excretion of all the essential trace metals examined was enhanced significantly, the tissue and serum levels of some of them either increased or decreased after administration of the chelators. The results suggest depletion of some of the endogenous trace metals from the body and their intertissue redistribution following treatment with these chelating agents.

摘要

研究了一剂、三剂和六剂乙二胺四乙酸（EDTA）、二乙烯三胺五乙酸（DTPA）和三亚乙基四胺（TETA）对大鼠尿中钙、铜、铁和锌排泄以及它们在肝脏、肾脏、心脏和血清中水平的影响，以确定它们在改善金属中毒方面的适用性。虽然所检测的所有必需微量元素的排泄均显著增加，但在给予螯合剂后，其中一些元素的组织和血清水平要么升高要么降低。结果表明，用这些螯合剂治疗后，体内一些内源性微量元素会从体内耗竭并在组织间重新分布。