Victery W, Miller C R, Goyer R A
J Lab Clin Med. 1986 Feb;107(2):129-35.
Urinary excretion of lead, zinc, calcium, magnesium, iron, copper, sodium, and potassium was measured in rats daily for 1 week after a 6-week exposure to 10,000 micrograms/ml lead in drinking water. Beginning on the third day, half of the lead-exposed and control rats were injected intraperitoneally with calcium disodium ethylenediaminetetraacetate (EDTA) daily for 3 days. Whole blood, plasma, and kidney metal concentrations were determined from samples obtained at the end of the experiment. Exposure to lead increased urinary excretion, not only of lead, but also of calcium, magnesium, zinc, copper, and iron. Excretion of sodium and potassium was not altered. Chelation therapy further increased excretion of lead, zinc, copper, and iron, but not magnesium. The increase in calcium excretion during chelation treatment (beyond that resulting from lead exposure per se) was accounted for by the Ca content of CaNa2-EDTA. EDTA treatment increased renal concentration of zinc but lowered renal concentration of lead, copper, and iron. These multimetal alterations may have implications for essential metal supplementation, particularly zinc, in persons being given chelation agents for excess lead exposure and in infants and children with low-level lead exposure not necessarily requiring chelation therapy.
在给予大鼠饮用含10,000微克/毫升铅的水6周后，连续1周每日测量其尿中铅、锌、钙、镁、铁、铜、钠和钾的排泄量。从第三天开始，对一半铅暴露大鼠和对照大鼠每日腹腔注射乙二胺四乙酸二钠钙（EDTA），共注射3天。在实验结束时从采集的样本中测定全血、血浆和肾脏中的金属浓度。铅暴露不仅增加了尿中铅的排泄，还增加了钙、镁、锌、铜和铁的排泄。钠和钾的排泄未发生改变。螯合疗法进一步增加了铅、锌、铜和铁的排泄，但未增加镁的排泄。螯合治疗期间钙排泄的增加（超过铅暴露本身导致的增加量）是由CaNa2-EDTA中的钙含量所致。EDTA治疗增加了肾脏中锌的浓度，但降低了铅、铜和铁的肾脏浓度。这些多种金属的变化可能对在因铅暴露过量而接受螯合剂治疗的人群以及不一定需要螯合疗法的低水平铅暴露婴儿和儿童中补充必需金属，尤其是锌，具有影响。
