Phromphetcharat V, Welbourne T C
Experientia. 1984 Oct 15;40(10):1144-6.
In chronic metabolic acidosis arterial plasma glutamine concentration is reduced 46%. This effect is attributable to a reduction in arterial pCO2 rather than acidemia since elevating pCO2 returns glutamine toward the control level. The extracellular glutamine precursors ammonia and glutamate exhibit a reciprocal decline with the elevation in pCO2. This reduction in metabolic acidosis appears to play an important role in sparing glutamine for renal base generation.
在慢性代谢性酸中毒中，动脉血浆谷氨酰胺浓度降低46%。这种效应归因于动脉血二氧化碳分压（pCO2）降低而非酸血症，因为提高pCO2可使谷氨酰胺水平恢复至对照水平。细胞外谷氨酰胺前体氨和谷氨酸随着pCO2升高呈反向下降。代谢性酸中毒时这种降低似乎在节省谷氨酰胺以供肾脏生成碱方面发挥重要作用。
