Ford R W, Malm D N
J Neurosurg. 1984 Nov;61(5):925-30. doi: 10.3171/jns.1984.61.5.0925.
Hypocarbia, normocarbia, or hypercarbia was maintained for an 8-hour period beginning 30 minutes after acute threshold spinal cord injuries in cats. No statistically significant differences in neurological recovery or histologically assessed tissue preservation were found among the three groups of animals 6 weeks after injury. No animal recovered the ability to walk. It is concluded that maintenance of hypercarbia or hypocarbia during the early postinjury period is no more therapeutic than maintenance of normocarbia. Mortality rates and tissue preservation data suggest, however, that postinjury hypocarbia may be less damaging than hypercarbia.
在猫急性阈值脊髓损伤30分钟后开始，将低碳酸血症、正常碳酸血症或高碳酸血症维持8小时。损伤6周后，三组动物在神经功能恢复或组织学评估的组织保存方面未发现统计学上的显著差异。没有动物恢复行走能力。得出的结论是，在损伤后早期维持高碳酸血症或低碳酸血症并不比维持正常碳酸血症更具治疗效果。然而，死亡率和组织保存数据表明，损伤后的低碳酸血症可能比高碳酸血症的损害更小。
