Hukuda S, Mochizuki T, Ogata M
Neurosurgery. 1980 Jun;6(6):644-8. doi: 10.1227/00006123-198006000-00005.
Combined hypertension and hypercarbia, which was found to improve post-traumatic spinal cord hypoxia and presumably ischemia in our previous study, was used in dogs subjected to experimental spinal cord injury to determine its therapeutic effects against acute spinal cord trauma. Intermittent hypertension and hypercarbia therapy, in which 15 minutes of hypertension and 95% O2:5% CO2 gas ventilation were alternated with 10 minutes of air ventilation, was given for 3 hours beginning 3 hours after injury. The treated dogs and untreated control dogs were checked neurologically and electrophysiologically at weekly intervals for up to 8 weeks. The treated dogs showed higher grades of neurological function within 1 week, but the results were statistically insignificant. Both groups demonstrated steady neurological improvement for the next 2 weeks and remained paraparetic thereafter with no group difference. The size of the intramedullary lesion was identical in both groups. Recovery of the somatosensory evoked potentials coincided well with neurological improvement, with again no difference between the two groups.
在我们之前的研究中发现，联合高血压和高碳酸血症可改善创伤后脊髓缺氧，并可能改善缺血情况。本研究将其用于遭受实验性脊髓损伤的犬类，以确定其对急性脊髓创伤的治疗效果。间歇性高血压和高碳酸血症治疗方法为，在损伤后3小时开始，每15分钟的高血压和95%氧气:5%二氧化碳气体通气与10分钟的空气通气交替进行，持续3小时。对治疗组犬和未治疗的对照组犬每周进行一次神经学和电生理学检查，最长检查8周。治疗组犬在1周内神经功能分级较高，但结果无统计学意义。两组在接下来的2周内神经功能均稳步改善，此后均仍为截瘫，两组之间无差异。两组髓内病变大小相同。体感诱发电位的恢复与神经功能改善情况非常吻合，两组之间同样无差异。
