Kurebe M, Asaoka H, Hata T, Izawa M, Watanabe T, Sawazaki S
Jpn J Antibiot. 1984 Jun;37(6):1211-27.
A perinatal and postnatal study of MT-141 was performed in SD rats. The dams were administered intramuscularly (i.m.) with MT-141 at the dose levels of 400, 800 and 1,600 mg/kg/day from the day 17 of gestation until the day 21 post delivery. The results are summarized as follows. No significant adverse effects of MT-141 were observed on the body weight gain, food consumption and water intake in dams of all groups treated with the drug during the perinatal and postnatal period. MT-141 did not change parameters of reproductive study in birth, development, physiological function and behavior of F1 rat. This compound had no effect on the fertility in F1 rats and also did not caused significant defects in the external appearance, viscera and skeleton of fetuses from dams (F1). It is concluded from these results that the maximal "no effective" dose of MT-141 is above 1,600 mg/kg/day i.m. for dams and the offsprings.
在SD大鼠中进行了MT - 141的围产期和产后研究。从妊娠第17天到产后第21天，给母鼠肌肉注射MT - 141，剂量分别为400、800和1600mg/kg/天。结果总结如下。在围产期和产后期间，所有用药组母鼠的体重增加、食物消耗和水摄入量均未观察到MT - 141的显著不良反应。MT - 141对F1代大鼠出生、发育、生理功能和行为的生殖研究参数没有影响。该化合物对F1代大鼠的生育能力没有影响，也未导致母鼠（F1）所产胎儿的外观、内脏和骨骼出现明显缺陷。从这些结果得出结论，MT - 141对母鼠和后代的最大“无效应”剂量高于肌肉注射1600mg/kg/天。
