Rusch V, Hyde R M, Luckey T D
Nahrung. 1984;28(6-7):699-709. doi: 10.1002/food.19840280649.
The treatment of mice with an injection preparation consisting of killed R-tribes of non-pathogenous E. coli caused an increase in microbicidic activities in the animal's blood and effects a significant protection against consecutive infections with Salmonella typhimurium. The enhancement of the animal' resistance capacity appears to be non-specific, and connected with the activity of leucocytes. Oral application of preparations of intestinal bacteria led to increased resistance against consecutive infections with Salmonella typhimurium and Haemophilus influenzae. Three different oral vaccines have been used: Streptococcus faecalis and E. coli, a viable vaccine of non-pathogenous Streptococcus faecalis and a viable vaccine of E. coli. The enhancement of the resistance can be attributed to an induction of the chemotactic efficiency of the animal neutrophilic cells. The chemotactic response of these cells seems to be enhanced. The mode of action of both the other oral vaccines remains obscure.
用由非致病性大肠杆菌的灭活R菌组成的注射制剂处理小鼠，可使动物血液中的杀菌活性增加，并对鼠伤寒沙门氏菌的连续感染产生显著的保护作用。动物抵抗力的增强似乎是非特异性的，且与白细胞的活性有关。口服肠道细菌制剂可增强对鼠伤寒沙门氏菌和流感嗜血杆菌连续感染的抵抗力。使用了三种不同的口服疫苗：粪肠球菌和大肠杆菌、非致病性粪肠球菌的活疫苗以及大肠杆菌的活疫苗。抵抗力的增强可归因于动物嗜中性细胞趋化效率的诱导。这些细胞的趋化反应似乎增强了。其他两种口服疫苗的作用方式仍不清楚。
