LaFramboise W A, Tuck R E, Woodrum D E, Guthrie R D
Pediatr Res. 1984 Oct;18(10):943-8. doi: 10.1203/00006450-198410000-00007.
Comparison between 21 2-day-old infant monkeys and 17 21-day-old infants during non-rapid eye movement sleep demonstrated that minute ventilation (VI) increased from 141 +/- 30 to 257 +/- 65 ml/min secondary to elevations in tidal volume (VT) and mean inspiratory flow (VT/Ti) with little change in respiratory timing. These volumetric parameters of ventilation as well as functional residual capacity remained significantly augmented when standardized for gain in body weight. Dynamic lung compliance increased from 0.69 +/- 0.19 to 0.89 +/- 0.39 ml/cm H2O with age while inspiratory pulmonary resistance did not change. Effective elastance fell significantly with maturation (5.27 +/- 1.51 cm H2O/ml on day 2 versus 4.15 +/- 1.35 cm H2O/ml on day 21) while effective impedance was elevated postnatally. The postnatal ventilatory gain (80% increase in VI) was attributable to increases both in dynamic lung compliance (30%) and inspiratory effort (50%) as determined by esophageal pressure changes. Isometric occlusion pressures (P0.1, P0.2 . . . Pmax) also significantly increased during this time span, suggesting that the increased ventilation resulted from an elevated respiratory drive.
对21只2日龄幼猴和17名21日龄婴儿在非快速眼动睡眠期间进行比较，结果表明，分钟通气量（VI）从141±30增加至257±65 ml/min，这主要是由于潮气量（VT）和平均吸气流量（VT/Ti）升高所致，呼吸时间变化不大。当按体重增加进行标准化时，这些通气的容积参数以及功能残气量仍显著增加。动态肺顺应性随年龄增长从0.69±0.19增加至0.89±0.39 ml/cm H2O，而吸气肺阻力未发生变化。有效弹性随成熟显著下降（第2天为5.27±1.51 cm H2O/ml，第21天为4.15±1.35 cm H2O/ml），而有效阻抗在出生后升高。出生后的通气增加（VI增加80%）归因于动态肺顺应性增加（30%）和吸气努力增加（50%），这是由食管压力变化所确定的。在此时间段内，等长阻塞压力（P0.1、P0.2……Pmax）也显著增加，这表明通气增加是由于呼吸驱动增强所致。
