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Neonatal-6-hydroxydopamine treatment: model of susceptibility for self-mutilation in the Lesch-Nyhan syndrome.

作者信息

Breese G R, Baumeister A A, McCown T J, Emerick S G, Frye G D, Mueller R A

出版信息

Pharmacol Biochem Behav. 1984 Sep;21(3):459-61. doi: 10.1016/s0091-3057(84)80110-0.

DOI:10.1016/s0091-3057(84)80110-0
PMID:6436840
Abstract

Neonatal-6-OHDA treated rats given L-DOPA after a decarboxylase inhibitor showed a high incidence of self-mutilation behavior (SMB) and self-biting. These behaviors were not observed in adult-6-OHDA-treated rats or in controls. Since inhibition of dopamine-beta-hydroxylase did not prevent or inhibit the SMB exhibited in neonatal-6-OHDA-treated rats after L-DOPA, norepinephrine is not likely to be contributing to this response. The age dependent effects observed are consistent with the hypothesis that neonatal reduction of dopamine-containing fibers is responsible for the SMB susceptibility observed in Lesch-Nyhan disease, making the neonatal-6-OHDA-treated rat a model of this neurological syndrome.

摘要

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