Lukas S E, Griffiths R R, Brady J V, Wurster R M
Psychopharmacology (Berl). 1984;83(4):316-20. doi: 10.1007/BF00428537.
Self-injection of phencyclidine HCI (PCP) and four of its analogues was examined in baboons. IV injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Self-injection performance was first established with cocaine and, once stable, test doses of each drug were substituted for 15 days. All five compounds maintained maximal self-injection performance, differing only in their relative potencies. The order of potency was approximately PCP greater than NMPCA = TCPY greater than NNBPCA greater than ketamine. Analysis of the distribution of injections throughout the day indicate that lower doses (and vehicle) were injected mainly during the daylight hours (i.e., 9 AM-6 PM), but as the dose was increased the injections became more uniformly distributed. Only the highest doses of these compounds affected food intake, though the degree of suppression was modest. No differences between these compounds with respect to their abuse potential could be found.
在狒狒身上研究了盐酸苯环利定（PCP）及其四种类似物的自我注射情况。静脉注射药物取决于完成160次杠杆按压（160次反应的固定比率程序）。每次注射后有3小时的休息期，每天最多可注射8次。首先用可卡因建立自我注射行为，一旦稳定，每种药物的测试剂量替代15天。所有五种化合物都维持了最大的自我注射行为，只是相对效力有所不同。效力顺序大致为PCP大于NMPCA = TCPY大于NNBPCA大于氯胺酮。对全天注射分布的分析表明，较低剂量（和赋形剂）主要在白天（即上午9点至下午6点）注射，但随着剂量增加，注射分布变得更加均匀。只有这些化合物的最高剂量会影响食物摄入，不过抑制程度适中。在这些化合物的滥用潜力方面未发现差异。
