Lamb R J, Griffiths R R
Psychopharmacology (Berl). 1987;91(3):268-72. doi: 10.1007/BF00518175.
MDMA (d,1-3,4-Methylenedioxymethamphetamine HCl; "ecstasy") self-injection (0.1-3.2 mg/kg/injection) was examined in baboons under conditions in which baseline responding was maintained by intravenous injections of cocaine HCl (0.32 mg/kg/injection). Drug was available under a FR 160-response schedule of intravenous injection. Each drug injection was followed by a 3-h time out allowing a maximum of eight injections per day. MDMA or MDMA vehicle (saline) was substituted for cocaine for a period of 14 or more days followed by a return to the cocaine baseline. MDMA (0.32-3.2 mg/kg/inj) maintained more injections and higher responses rates than were maintained by saline. The maximal number of injections maintained by MDMA and the maximal response rate maintained by MDMA were less than those maintained under baseline conditions with cocaine. The highest dose of MDMA tested maintained a cyclic pattern of self-injection, i.e., days of high numbers of injections intermixed with days of low numbers of injections. At the highest dose of MDMA tested, concurrent food maintained behavior was suppressed to an extent that food intake was also decreased.
在狒狒中研究了摇头丸（d，1-3,4-亚甲基二氧甲基苯丙胺盐酸盐；“摇头丸”）的自我注射（0.1 - 3.2毫克/千克/注射），实验条件是通过静脉注射盐酸可卡因（0.32毫克/千克/注射）来维持基线反应。药物可通过静脉注射的FR 160反应程序获得。每次药物注射后有3小时的休息时间，每天最多允许注射8次。用摇头丸或摇头丸溶媒（生理盐水）替代可卡因14天或更长时间，然后恢复到可卡因基线。与生理盐水相比，摇头丸（0.32 - 3.2毫克/千克/注射）能维持更多的注射次数和更高的反应率。摇头丸维持的最大注射次数和最大反应率低于可卡因基线条件下维持的水平。所测试的最高剂量摇头丸维持了一种自我注射的循环模式，即注射次数多的日子与注射次数少的日子交替出现。在所测试的最高剂量摇头丸下，同时进行的食物维持行为受到抑制，以至于食物摄入量也减少了。
