Wagner G C, Franko C M, Tomie A
Pharmacol Biochem Behav. 1984 Mar;20(3):379-82. doi: 10.1016/0091-3057(84)90274-0.
Phencyclidine (PCP), naloxone and haloperidol were administered alone and in combination to rats trained to drink sweetened-condensed milk during a 20 min daily session. PCP (1.0-16.0 mg/kg) produced a dose-dependent decrease in milk intake. All doses of naloxone (0.1-16.0 mg/kg) produced approximately a 30% decrease in milk intake. Haloperidol (0.125 mg/kg) had virtually no effect on milk intake. When a dose of naloxone which reduced milk intake by approximately 30% (8.0 mg/kg) was administered as a pretreatment to the PCP, the PCP curve was shifted to the left (lowered) to that degree. When haloperidol (0.125 mg/kg) was administered as a pretreatment to the PCP, the PCP dose-response curve was shifted 1.5 fold to the right. These interactions are similar to those observed in other behavioral paradigms and are discussed in reference to PCP's actions as an indirect dopaminergic agonist.
将苯环己哌啶（PCP）、纳洛酮和氟哌啶醇单独及联合给予在每日20分钟时段内训练饮用炼乳的大鼠。PCP（1.0 - 16.0毫克/千克）使乳汁摄入量呈剂量依赖性减少。所有剂量的纳洛酮（0.1 - 16.0毫克/千克）使乳汁摄入量减少约30%。氟哌啶醇（0.125毫克/千克）对乳汁摄入量几乎没有影响。当将使乳汁摄入量减少约30%的剂量的纳洛酮（8.0毫克/千克）作为PCP的预处理给药时，PCP曲线向左（降低）移动了该程度。当将氟哌啶醇（0.125毫克/千克）作为PCP的预处理给药时，PCP剂量 - 反应曲线向右移动了1.5倍。这些相互作用与在其他行为范式中观察到的相似，并参考PCP作为间接多巴胺能激动剂的作用进行了讨论。
