Wesnes K, Revell A
Psychopharmacology (Berl). 1984;84(1):5-11. doi: 10.1007/BF00432014.
Previous work in this and another laboratory has shown that nicotine tablets improve the performance of a rapid information processing task and reduce the Stroop effect, whereas scopolamine has the opposite effects. The purpose of this study was to extend these previous findings by determining whether, when administered together, these two drugs have mutually antagonistic effects on task performance. Two experiments are reported, both using within-subjects double-blind Latin Square designs. In the first, six subjects received single and combined doses of scopolamine 1.2 mg and nicotine 1.5 mg, and there was some evidence that the two drugs had mutually antagonistic effects on the rapid information processing task. In the second experiment 12 subjects received the same doses, but rapid information processing testing was carried out over a longer time period and Stroop testing was introduced at the end of the 2.5 h session. Nicotine was found to counteract the depression of performance produced by scopolamine on both the rapid information task and the Stroop test. These results provide further support for the theory that central cholinergic pathways play a major role in human information processing.
本实验室及另一实验室之前的研究表明，尼古丁片可改善快速信息处理任务的表现并减轻斯特鲁普效应，而东莨菪碱则有相反作用。本研究的目的是通过确定这两种药物同时给药时是否对任务表现产生相互拮抗作用来扩展之前的这些发现。报告了两项实验，均采用受试者内双盲拉丁方设计。在第一个实验中，6名受试者接受了1.2毫克东莨菪碱和1.5毫克尼古丁的单次及联合剂量，有一些证据表明这两种药物对快速信息处理任务有相互拮抗作用。在第二个实验中，12名受试者接受了相同剂量，但快速信息处理测试在更长时间段内进行，且在2.5小时的实验结束时引入了斯特鲁普测试。结果发现，尼古丁可抵消东莨菪碱对快速信息任务和斯特鲁普测试所产生的表现抑制。这些结果为中枢胆碱能通路在人类信息处理中起主要作用这一理论提供了进一步支持。
