Kostowski W, Dyr W, Zacharski B
Psychopharmacology (Berl). 1984;84(1):85-90. doi: 10.1007/BF00432031.
The influence of repeated and single administrations of desipramine, amitryptiline, and mianserin on the EEG effects of clonidine has been investigated in rats implanted with chronic cortical electrodes. Clonidine induced a dose-dependent EEG synchronization in control animals. Signs of behavioral depression occurred after administration of moderate (0.1 mg/kg) and higher (0.2 mg/kg) doses of clonidine. Single doses of desipramine and amitryptiline attenuated the clonidine effect, while mianserine potentiated clonidine-induced synchronization. Antidepressants given once daily for 14 days completely (desipramine and amitryptiline) or partially (mianserin) reduced the effect of clonidine. Antidepressants alone produced only a slight effect on cortical EEG pattern.
在植入慢性皮层电极的大鼠中，研究了去甲丙咪嗪、阿米替林和米安色林单次及重复给药对可乐定脑电图效应的影响。可乐定在对照动物中诱导出剂量依赖性的脑电图同步化。给予中等剂量（0.1mg/kg）和高剂量（0.2mg/kg）可乐定后出现行为抑郁迹象。单次给予去甲丙咪嗪和阿米替林可减弱可乐定的效应，而米安色林则增强可乐定诱导的同步化。连续14天每日给药一次的抗抑郁药完全（去甲丙咪嗪和阿米替林）或部分（米安色林）降低了可乐定的效应。单独使用抗抑郁药对皮层脑电图模式仅有轻微影响。
