Hyodo I, Yamada G, Nishihara T, Okushin H, Kinoyama S, Sakamoto Y, Tobe K, Nagashima H
Acta Med Okayama. 1984 Aug;38(4):389-401. doi: 10.18926/AMO/30310.
The incidence of hepatitis A (HA), hepatitis B (HB), and non-A, non-B hepatitis (NANBH) was 27%, 30% and 43% among 73 patients with sporadic hepatitis. Epidemiological data (geographical distribution, seasonal variation, age, sex, and occupation) were not distinguishing of the type of hepatitis. Neither intrafamilial infection nor previous contact with viral hepatitis patients could be demonstrated in the NANBH cases. Fever and jaundice were less frequent in NANBH than in HA. Maximum levels of SGPT, serum bilirubin, ZTT, and gamma-globulin were significantly lower in NANBH than in HA and HB. Ten of 29 NANBH patients (35%) presented abnormal SGPT activities for more than 6 months, and four (14%) more than 12 months. In the ten patients with prolonged courses, jaundice was more frequent and maximum levels of SGPT were higher than in patients with transient courses. Histopathologic findings were not markedly different from those of HA and HB. Bile duct damage, fatty deposition, and giant multi-nucleated cells were recognized in 6, 12, and 2 NANBH patients, respectively. There were no characteristic ultrastructural changes in NANBH.
在73例散发性肝炎患者中，甲型肝炎（HA）、乙型肝炎（HB）和非甲非乙型肝炎（NANBH）的发病率分别为27%、30%和43%。流行病学数据（地理分布、季节变化、年龄、性别和职业）无法区分肝炎类型。在NANBH病例中，既未证实有家庭内感染，也未发现此前与病毒性肝炎患者有过接触。与HA相比，NANBH患者发热和黄疸的情况较少见。NANBH患者的谷丙转氨酶（SGPT）、血清胆红素、锌浊度（ZTT）和γ-球蛋白的最高水平显著低于HA和HB患者。29例NANBH患者中有10例（35%）SGPT活性异常超过6个月，4例（14%）超过12个月。在病程延长的10例患者中，黄疸更为常见，SGPT的最高水平高于病程短暂的患者。组织病理学检查结果与HA和HB无明显差异。分别在6例、12例和2例NANBH患者中发现胆管损伤、脂肪沉积和巨大多核细胞。NANBH没有特征性的超微结构变化。
