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通过连续测定血清中单胺氧化酶和二胺氧化酶来监测肺癌治疗情况。

Monitoring treatment of pulmonary carcinomas by serial determination of monoamine oxidase and diamine oxidase in blood serum.

作者信息

Kamiński K A, Bodziony J, Kozielski J

出版信息

Arch Geschwulstforsch. 1984;54(5):377-85.

PMID:6437369
Abstract

We investigated monoamine oxidase (MAO--E.C. 1.4.3.4.) and diamine oxidase (DAO--E. C. 1.4.3.6.) in the serum of patients with lung cancer, treated with chemo- and radiotherapy. These enzyme activities were determined with tyramine and putrescine as substrates. The MAO activities of serum and DAO serum increased notably in some cases of lung cancer. These results are discussed in light of the postulated role of this enzyme in cell division and in the tumor development process.

摘要

我们研究了接受化疗和放疗的肺癌患者血清中的单胺氧化酶(MAO - E.C. 1.4.3.4.)和二胺氧化酶(DAO - E.C. 1.4.3.6.)。以酪胺和腐胺为底物测定这些酶的活性。在某些肺癌病例中,血清中的MAO活性和DAO血清活性显著增加。根据该酶在细胞分裂和肿瘤发展过程中假定的作用对这些结果进行了讨论。

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