Essin D J
Biochem Med. 1984 Aug;32(1):67-78. doi: 10.1016/0006-2944(84)90009-7.
The Base Excess of the Extracellular Fluid (BE-ecf) is the most complete model of acid-base physiology. It has gained considerable acceptance for use in adults as an index of the metabolic component of an acute acid-base disturbance. Several other commonly used indices were compared to the BE-ecf. The values of the Base Excess of Blood, Plasma Bicarbonate, Standard Bicarbonate, and T40-Bicarbonate differed significantly from the BE-ecf in 11.4, 6.3, 12.5, and 1.1% of samples, respectively. These differences are considered to be errors since the nonlinear relationship of the variables makes it difficult to clinically accommodate them. The standard (adult) form of the BE-ecf calculation overestimated the base excess by 1 meq/liter in 44.8% and by 2 meq/liter or more in 6.1% of samples from neonates and infants when compared to a form of the calculation which was individually adjusted based on the weight and hemoglobin concentration of each subject. Since it is no more difficult to make these corrections than to ignore them, if the BE-ecf is to be used in neonates and infants the correction should be applied.
细胞外液碱剩余（BE-ecf）是酸碱生理学中最完整的模型。它作为急性酸碱紊乱代谢成分的指标在成人中已得到广泛认可。将其他几个常用指标与BE-ecf进行了比较。血碱剩余、血浆碳酸氢盐、标准碳酸氢盐和T40-碳酸氢盐的值分别在11.4%、6.3%、12.5%和1.1%的样本中与BE-ecf有显著差异。由于变量的非线性关系使得临床上难以处理这些差异，所以这些差异被认为是误差。与根据每个受试者的体重和血红蛋白浓度单独调整的计算形式相比，BE-ecf计算的标准（成人）形式在44.8%的新生儿和婴儿样本中高估碱剩余1毫当量/升，在6.1%的样本中高估2毫当量/升或更多。由于进行这些校正并不比忽略它们更困难，所以如果要在新生儿和婴儿中使用BE-ecf，就应该进行校正。
