大鼠蓝斑双侧损伤后吗啡镇痛作用减弱。
Reduced analgesic effects of morphine after bilateral lesions of the locus coeruleus in rats.
作者信息
Kostowski W, Jerlicz M, Bidziński A, Hauptmann M
出版信息
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):49-53.
PMID:643740
Abstract
Noradnenaline-depleting lesions involving the locus coerulcus markedly reduced morphine analgesia. Rats were tested for analgesia using the tail-compression method. The results indicate that locus coeruleus plays an important role in analgesic action of morphine.
摘要
涉及蓝斑核的去甲肾上腺素耗竭性损伤显著降低了吗啡镇痛效果。使用尾部压迫法对大鼠进行镇痛测试。结果表明，蓝斑核对吗啡的镇痛作用起着重要作用。
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