Chilcoat R T, Lunn J N, Mapleson W W
Br J Anaesth. 1984 Dec;56(12):1417-32. doi: 10.1093/bja/56.12.1417.
A control system was used to bring the tension of anaesthetic in the brain to any value specified (in MAC units) by the anaesthetist and then maintain it constant until a new value was specified. The control was applied to a volatile agent but allowance was automatically made for the anaesthetic effect of any nitrous oxide concomitantly administered by the anaesthetist. The inspired concentration required to achieve the desired brain tension was calculated from a model of the patient and set automatically on the vaporizer. The quantification of the model was matched to the patient on the basis mainly of body mass and periodic non-invasive measurements of alveolar ventilation and cardiac output. In order to adapt the model to the patient an arterial blood sample was taken every 30 min to obtain the arterial tension of halothane for use as feedback. The system has been tested on eight Alsatian dogs. After omitting results affected by avoidable errors, the SD of the measured-to-computed arterial tension ratio was less than 10%.
使用一个控制系统将大脑中麻醉剂的张力调节至麻醉师指定的任何值（以MAC单位计），然后保持恒定，直到指定新的值。该控制应用于挥发性麻醉剂，但会自动考虑麻醉师同时给予的任何一氧化二氮的麻醉效果。根据患者模型计算达到所需大脑张力所需的吸入浓度，并在蒸发器上自动设置。该模型的量化主要基于体重以及肺泡通气和心输出量的定期无创测量来与患者匹配。为了使模型适应患者，每30分钟采集一次动脉血样以获取氟烷的动脉张力用作反馈。该系统已在8只阿尔萨斯犬身上进行了测试。在剔除受可避免误差影响的结果后，实测与计算的动脉张力比值的标准差小于10%。
