D，L-α-二氟甲基鸟氨酸对小鼠乳腺癌发生的影响。
Effect of D,L-alpha-difluoromethylornithine on murine mammary carcinogenesis.
作者信息
Thompson H J, Herbst E J, Meeker L D, Minocha R, Ronan A M, Fite R
出版信息
Carcinogenesis. 1984 Dec;5(12):1649-51. doi: 10.1093/carcin/5.12.1649.
PMID:6437694
Abstract
The development of chemically-induced mammary gland carcinomas in rats was dramatically suppressed by provision of a 1% solution of D,L-alpha-difluoromethylornithine (DFMO) in drinking water. Treatment with DFMO significantly reduced cancer incidence and the average size and number of cancers per rat and prolonged the cancer-free time. DFMO appears to be effective in blocking some aspect of the promotion stage of chemically induced mammary carcinogenesis in the rat.
摘要
通过在饮用水中提供1%的D，L-α-二氟甲基鸟氨酸（DFMO）溶液，可显著抑制大鼠化学诱导性乳腺癌的发生。用DFMO治疗可显著降低癌症发病率、每只大鼠的癌症平均大小和数量，并延长无癌时间。DFMO似乎在阻断大鼠化学诱导性乳腺癌发生促进阶段的某些方面有效。
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