锂在治疗剂量时可导致严重的窦房结功能障碍。

Lithium causing a serious sinus-node dysfunction at therapeutic doses.

作者信息

Montalescot G, Levy Y, Farge D, Brochard L, Fantin B, Arnoux C, Hatt P Y

出版信息

Clin Cardiol. 1984 Nov;7(11):617-20. doi: 10.1002/clc.4960071113.

Abstract

The cardiovascular effects of lithium have been indexed in literature since 1900, most frequently in cases of intoxication. We recently studied the exceptional case of a patient showing a serious sinus node dysfunction during lithium treatment. The serum lithium levels were always within the therapeutic range. After two endocardial explorations and withdrawal of lithium, we found that the sinus node dysfunction was due to lithium and reversible after withdrawal of it. Some ignored dysfunctions could exist with a regularly controlled treatment.

摘要

自1900年以来，锂对心血管系统的影响在文献中已有记载，最常见于中毒病例。我们最近研究了一个特殊病例，该患者在锂治疗期间出现严重的窦房结功能障碍。血清锂水平始终在治疗范围内。经过两次心内膜探查并停用锂后，我们发现窦房结功能障碍是由锂引起的，停用锂后可逆转。在常规控制治疗过程中可能存在一些被忽视的功能障碍。