Korewicki J, Kraska T, Opolski G, Ostrzycki A, Pałynyczko Z
Eur Heart J. 1984 Sep;5(9):697-704. doi: 10.1093/oxfordjournals.eurheartj.a061729.
The effects of intravenous nitroglycerin (TNG) were evaluated in 39 patients with a first acute myocardial infarction, subdivided according to Killip into those with left ventricular failure (N = 24) and those without (N = 15). A group of 38 randomly selected patients treated in a conventional, but unstandardized manner, served as a control (C). TNG caused a statistically significant reduction in pulmonary artery diastolic pressure, regardless of its initial value, by about 30%. Neither cardiac index nor total peripheral resistance was significantly changed. Infarct size, measured in gEq of isoenzyme MB creatine kinase (CK-MB), was smaller by about 40% in both subgroups of patients treated with TNG, when compared with the controls. A significant difference was found in peak CK-MB blood levels only in the group of patients with left ventricular failure (Killip classes II and III) treated with TNG. The best results were obtained when TNG was given not later than 4 h after the onset of the symptoms of infarction.
对39例首次发生急性心肌梗死的患者进行了静脉滴注硝酸甘油（TNG）效果的评估，这些患者根据Killip分级分为左心室衰竭患者（N = 24）和无左心室衰竭患者（N = 15）。一组38例以常规但未标准化方式治疗的随机选择患者作为对照（C）。无论肺动脉舒张压初始值如何，TNG均可使其显著降低约30%。心脏指数和总外周阻力均无显著变化。与对照组相比，用TNG治疗的两个亚组患者中，以肌酸激酶同工酶MB（CK-MB）的克当量表示的梗死面积均减小约40%。仅在接受TNG治疗的左心室衰竭患者组（Killip分级II和III级）中，CK-MB血药峰值水平存在显著差异。在梗死症状出现后不迟于4小时给予TNG时，效果最佳。
