[碳酸锂对利钠因子作用的影响]
[Influence of lithium carbonate on the effects of the natriuretic factor].
作者信息
Kosuba R B, Nevskaia T L, Ivanov Iu I
出版信息
Farmakol Toksikol. 1984 Sep-Oct;47(5):15-8.
PMID:6437861
Abstract
It has been shown in rat experiments that administration of lithium carbonate for 3 days (100 mg/kg) enhances renal excretion of water and electrolytes following an increase in the volume of extracellular fluid. In this case renal excretion of natriuretic factor rises, whereas its concentration in blood plasma does not ascend. Lithium carbonate raises the sensitivity of the kidneys to natriuretic factor and reduces its effect on transport activity in the small intestine.
摘要
大鼠实验表明，连续3天给予碳酸锂（100毫克/千克）后，随着细胞外液量增加，肾脏对水和电解质的排泄增强。在这种情况下，利钠因子的肾脏排泄增加，而其血浆浓度并未升高。碳酸锂提高了肾脏对利钠因子的敏感性，并降低了其对小肠转运活性的影响。
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