钙离子载体A 23187对培养的人成纤维细胞中低密度脂蛋白加工及脂质代谢的影响。

Effects of the calcium ionophore A 23187 on low-density lipoprotein processing and lipid metabolism in cultured human fibroblasts.

作者信息

Mazière J C, Mazière C, Mora L, Gardette J, Polonovski J

出版信息

FEBS Lett. 1984 Nov 5;177(1):76-80. doi: 10.1016/0014-5793(84)80984-9.

DOI:10.1016/0014-5793(84)80984-9

Abstract

Pretreatment of cultured human fibroblasts with the calcium ionophore A 23187 resulted in a decrease in low-density lipoprotein internalization. This effect was dose-dependent and did not occur in a medium devoid of calcium. About 2-fold reduction was observed with 10(-5)M A 23187. In contrast, the low-density lipoprotein binding was only slightly affected. The incorporation of [14C]acetate and [14C]oleate into all classes of lipids (sterol, triacylglycerols and phospholipids) was strikingly reduced by ionophore pretreatment.

摘要

用钙离子载体A 23187对培养的人成纤维细胞进行预处理，会导致低密度脂蛋白内化减少。这种效应呈剂量依赖性，在无钙培养基中不会发生。用10(-5)M A 23187处理时，观察到约2倍的降低。相比之下，低密度脂蛋白结合仅受到轻微影响。离子载体预处理显著降低了[14C]乙酸盐和[14C]油酸酯掺入所有脂质类别（固醇、三酰甘油和磷脂）中的量。

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