Murison G L, Hall S D, Lee A M
Exp Cell Biol. 1984;52(6):355-60. doi: 10.1159/000163282.
A recently established rat liver cell line, RL-12, exhibits an unusually high sensitivity to the genotoxic effects of a number of selected procarcinogens. Significant reductions in cell survival (D37%) and induction of sister chromatid exchanges were obtained with 1 X 10(-9) M benzo[a]pyrene and 2 X 10(-8) M 7,12-dimethylbenz[a]anthracene. This rat liver epithelial cell line may serve as a useful model system to study the metabolic activation of procarcinogens to their ultimate genotoxic form.
一种最近建立的大鼠肝细胞系RL - 12，对多种选定的前致癌物的遗传毒性作用表现出异常高的敏感性。用1×10⁻⁹ M苯并[a]芘和2×10⁻⁸ M 7,12 - 二甲基苯并[a]蒽可使细胞存活率（D37%）显著降低，并诱导姐妹染色单体交换。这种大鼠肝上皮细胞系可作为一个有用的模型系统，用于研究前致癌物代谢活化为其最终遗传毒性形式的过程。
