在经从铜绿假单胞菌纯化的黏液多糖处理的巨噬细胞培养物中酵母吞噬作用的抑制。
Inhibition of yeast phagocytosis in macrophage cultures treated with slime polysaccharide purified from Pseudomonas aeruginosa.
作者信息
Grasso R J, Ganguly R, Breen J F
出版信息
J Leukoc Biol. 1984 Dec;36(6):771-4. doi: 10.1002/jlb.36.6.771.
PMID:6438263
Abstract
This study was initiated to determine whether purified slime polysaccharide(PSP) from P aeruginosa inhibits the ingestion of heat killed Saccharomyces cerevisiae particles in macrophage cultures. Relative to controls, direct phagocytosis assays revealed that the percentages of phagocytes and the numbers of ingested yeast particles per phagocyte decreased in a dose-dependent manner in PSP-treated cultures. Thus, PSP may act as a virulence factor in vivo by impairing the phagocytic capacity of macrophages.
摘要
开展本研究以确定从铜绿假单胞菌中纯化得到的黏液多糖（PSP）是否会抑制巨噬细胞培养物中热杀死的酿酒酵母颗粒的摄取。与对照组相比，直接吞噬试验显示，在PSP处理的培养物中，吞噬细胞的百分比和每个吞噬细胞摄取的酵母颗粒数量呈剂量依赖性下降。因此，PSP可能通过损害巨噬细胞的吞噬能力在体内充当一种毒力因子。
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