Yoshimoto M, Sakamoto G, Sugano H, Kasumi F, Fukami A, Kuno K
Gan No Rinsho. 1984 Sep;30(11):1361-8.
The influence of family history, irradiation and anti-cancer drug (Mitomycin C) on the occurrence of multiple primary neoplasms was analysed using the person-year method in 1359 Japanese breast carcinoma patients. There were 111 multiple primary neoplasms, including bilateral breast cancer, in 109 patients; the incidence rate was 0.0072 per person-year. The incidence rate in patients with a family history of cancer was 1.29 times higher than in those without. In the bilateral breast cancer group there was about a 3 times higher frequency of family history of breast cancer. Irradiation therapy raised the occurrence of multiple primary neoplasms 1.28 fold, and Mitomycin C (40 mg) had no effect on the occurrence of neoplasms during a 10-year observation period.
采用人年法，对1359例日本乳腺癌患者的家族史、放疗及抗癌药物（丝裂霉素C）对多原发性肿瘤发生的影响进行了分析。109例患者发生了111例多原发性肿瘤，包括双侧乳腺癌；发病率为每人年0.0072。有癌症家族史的患者发病率比无家族史的患者高1.29倍。在双侧乳腺癌组中，乳腺癌家族史的频率约高3倍。放射治疗使多原发性肿瘤的发生率提高了1.28倍，在10年观察期内，丝裂霉素C（40mg）对肿瘤发生无影响。
