Gogas J, Markopoulos C, Skandalakis P, Gogas H
Second Propedeutic Department of Surgery, University of Athens, Greece.
Am Surg. 1993 Nov;59(11):733-5.
Seventy-eight confirmed cases of second primary breast cancer in the contralateral breast were encountered over a 22-year period in 1332 women with invasive breast cancer treated in our department. Tumors were grouped into those simultaneously detected in both breasts or within 6 months of each other (synchronous, 1.6%) and those detected within more than 6 months (metachronous, 4.2%). The mean interval between metachronous cancers was 117 months. Patients with bilateral tumors were more likely to have a family history of breast cancer than those with unilateral disease. Women with metachronous tumors tended to be younger when diagnosed with the first carcinoma as compared with those having unilateral or synchronous bilateral cancers. No differences were noticed in size and lymph node status between the first or second tumor of bilateral cases in comparison to patients with unilateral disease. Significantly more (P < 0.05) first metachronous tumors were found to be lobular invasive cancers. Histopathologic type of the first tumor was the same as the second in 62.8 per cent of all cases. Concordance of estrogen receptor status between bilateral tumors was 71.4 per cent. Our results indicate that the risk of developing, a contralateral breast cancer is related to the patient's age, family history of breast cancer, and lobular histology of the tumor.
在我们科室接受治疗的1332例浸润性乳腺癌女性患者中，在22年期间发现了78例对侧乳腺发生第二原发性乳腺癌的确诊病例。肿瘤被分为在双侧乳房同时检测到或在彼此6个月内检测到的（同步性，1.6%）以及在6个月以上检测到的（异时性，4.2%）。异时性癌症之间的平均间隔为117个月。双侧肿瘤患者比单侧疾病患者更有可能有乳腺癌家族史。与患有单侧或同步双侧癌症的女性相比，患有异时性肿瘤的女性在被诊断出首例癌症时往往更年轻。与单侧疾病患者相比，双侧病例的首例或第二例肿瘤在大小和淋巴结状态方面没有差异。发现明显更多（P<0.05）的首例异时性肿瘤为小叶浸润癌。在所有病例中，62.8%的首例肿瘤组织病理学类型与第二例相同。双侧肿瘤之间雌激素受体状态的一致性为71.4%。我们的结果表明发生对侧乳腺癌的风险与患者年龄、乳腺癌家族史以及肿瘤的小叶组织学有关。
