[Insulin-like substance in the submaxillary glands of mice normally and in alloxan diabetes].

The content of an insulin-like substance, revealed in the submaxillary glands of mice by means of the radioimmunological method proved to decrease in alloxan diabetes, still remaining higher than in the blood serum of the same animals. Cells of the granular portions of the salivary ducts underwent some ultrastructural changes in this disease. The exogenous 125I-insulin was capable of being included into the cells of the salivary ducts. The percentage of labeled cells in these portions considerably exceeded such in acini of the submaxillary and the pancreatic ducts, and also in the islar cells. Incorporation of 125I-insulin into the salivary ducts proved to diminish in alloxan diabetes.