编码人抗血友病因子的cDNA的分子克隆
Molecular cloning of a cDNA encoding human antihaemophilic factor.
作者信息
Toole J J, Knopf J L, Wozney J M, Sultzman L A, Buecker J L, Pittman D D, Kaufman R J, Brown E, Shoemaker C, Orr E C
出版信息
Nature. 1984;312(5992):342-7. doi: 10.1038/312342a0.
DOI:10.1038/312342a0
PMID:6438528
Abstract
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.
摘要
编码人凝血因子VIII:C的mRNA序列的完整拷贝已被克隆并表达。DNA序列预测其为一个含2351个氨基酸的单链前体，相对分子质量（Mr）为267,039。该蛋白质具有明显的结构域结构，包含序列重复，并且在结构上与因子V和铜蓝蛋白相关。
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