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6-羟基多巴胺诱导豚鼠产生的心脏去神经超敏反应。

Cardiac denervation supersensitivity produced in guinea pigs by 6-hydroxy-dopamine.

作者信息

Shavit S, Gassner S, Korczyn A D

出版信息

Pharmacol Res Commun. 1984 Feb;16(2):171-9. doi: 10.1016/s0031-6989(84)80092-2.

DOI:10.1016/s0031-6989(84)80092-2
PMID:6438652
Abstract

The effects of chemical sympathectomy with 6-hydroxydopamine (6-OH-DA) on the sensitivity of guinea-pig heart to catecholamines were studied. Heart rate at rest and chronotropic effects of catecholamines remained unchanged after chemical sympathectomy, while the arrhythmogenic effects of epinephrine, norepinephrine and isoprenaline were potentiated markedly. Our results indicate that chemical sympathectomy with 6-OH-DA produced post synaptic denervation supersensitivity in the heart ventricles.

摘要

研究了用6-羟基多巴胺（6-OH-DA）进行化学交感神经切除术对豚鼠心脏对儿茶酚胺敏感性的影响。化学交感神经切除术后，静息心率和儿茶酚胺的变时作用保持不变，而肾上腺素、去甲肾上腺素和异丙肾上腺素的致心律失常作用则明显增强。我们的结果表明，用6-OH-DA进行化学交感神经切除术可使心室产生突触后去神经超敏反应。

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