Ekström J
Acta Pharmacol Toxicol (Copenh). 1979 May;44(5):377-84.
6-hydroxydopamine (100 mg/kg injected intravenously twice with a weekly interval) was used for the destruction of the adrenergic nerves in the rat detrusor muscle. Two to three weeks after the first injection of this substance the sensitivity of the detrusor muscle to parasympathomimetic and sympathomimetic drugs was tested by recording the intravesical pressure in situ. The sensitivity to methacholine was found to be unchanged, whereas a supersensitivity to noradrenaline, adrenaline, phenylephrine and isoprenaline was found to have developed, thus involving both alpha-adrenoceptor mediated contraction and beta-adrenoceptor mediated relaxation. The supersensitivity was of the postjunctional type.
6-羟基多巴胺（100毫克/千克，静脉注射，每周间隔一次，共两次）用于破坏大鼠逼尿肌中的肾上腺素能神经。首次注射该物质两到三周后，通过记录膀胱内原位压力来测试逼尿肌对拟副交感神经药和拟交感神经药的敏感性。发现对乙酰甲胆碱的敏感性未改变，而对去甲肾上腺素、肾上腺素、去氧肾上腺素和异丙肾上腺素出现了超敏反应，因此涉及α-肾上腺素能受体介导的收缩和β-肾上腺素能受体介导的舒张。这种超敏反应属于节后型。
