丁基羟基茴香醚（BHA）和丁基羟基甲苯（BHT）对大鼠肝脏微粒体代谢N，N-二甲基-4-氨基偶氮苯（DAB）的影响。

Effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on metabolism of N,N-dimethyl-4-aminoazobenzene (DAB) by rat liver microsomes.

作者信息

Levine W G

出版信息

Res Commun Chem Pathol Pharmacol. 1984 Oct;46(1):113-20.

Abstract

The antioxidants, BHA and BHT, inhibited the N-demethylation and ring hydroxylation of N,N-dimethyl-4-aminoazobenzene (DAB) by liver microsomes from untreated and phenobarbital (PB)-treated rats. BHA was somewhat more potent in this regard than was BHT. Microsomal NADPH oxidase from PB-treated rats was stimulated by BHA but control microsomal activity was unaffected. Glutathione did not appreciably reverse the inhibitory effect of BHA on DAB metabolism and had no effect on NADPH oxidase activity. It is concluded that inhibition of DAB metabolism by BHA cannot be accounted for by interaction with NADPH oxidase, particularly in untreated microsomes. It more likely affects one or more species of cytochrome P-450.

摘要

抗氧化剂丁基羟基茴香醚（BHA）和二丁基羟基甲苯（BHT）可抑制未处理大鼠和经苯巴比妥（PB）处理大鼠肝脏微粒体对N，N-二甲基-4-氨基偶氮苯（DAB）的N-脱甲基作用和环羟基化作用。在这方面，BHA比BHT的效力稍强。BHA可刺激经PB处理大鼠的微粒体NADPH氧化酶，但对对照微粒体活性无影响。谷胱甘肽并未明显逆转BHA对DAB代谢的抑制作用，且对NADPH氧化酶活性无影响。得出的结论是，BHA对DAB代谢的抑制作用不能通过与NADPH氧化酶相互作用来解释，尤其是在未处理的微粒体中。它更有可能影响一种或多种细胞色素P-450。

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