von Unruh G E, Froescher W, Hoffmann F, Niesen M
Ther Drug Monit. 1984;6(3):272-6. doi: 10.1097/00007691-198409000-00003.
Valproic acid (VPA) concentrations were measured by a sensitive and highly specific gas chromatographic/mass spectrometric assay in breast milk from 16 patients treated with VPA during 17 lactation periods. The range of VPA levels in 36 breast milk samples was 0.4-3.9 micrograms/ml (mean 1.9 +/- 1.2 microgram/ml). During the investigations of breast milk it was found that the concentration of total VPA in breast milk was not much higher than that of unbound VPA. These findings agree with clinical observations of infants fed with milk from VPA-treated mothers.
采用灵敏且高度特异的气相色谱/质谱分析法，对17个哺乳期内接受丙戊酸（VPA）治疗的16例患者的母乳中的丙戊酸浓度进行了测定。36份母乳样本中丙戊酸水平范围为0.4 - 3.9微克/毫升（平均1.9±1.2微克/毫升）。在对母乳的研究过程中发现，母乳中丙戊酸的总浓度并不比游离丙戊酸的浓度高很多。这些发现与对食用接受丙戊酸治疗母亲的乳汁的婴儿的临床观察结果相符。
