Kosiagin D V
Ukr Biokhim Zh (1978). 1984 Sep-Oct;56(5):549-51.
Proteoglycan protein of human articular cartilage is found to contain a considerable amount of leucine, proline, glutaminic acid and glycine. The amino acid composition of various proteoglycan fractions differs in the methionine content. Proteoglycan protein from the degeneratively changed cartilage contains a less amount of lysine and serine. It is supposed that the found changes may be induced by the atypical synthesis of the proteoglycan protein shaft by chondrocytes under the cartilage degeneration.
研究发现，人关节软骨的蛋白聚糖蛋白含有大量的亮氨酸、脯氨酸、谷氨酸和甘氨酸。不同蛋白聚糖组分的氨基酸组成在蛋氨酸含量上有所不同。退变软骨中的蛋白聚糖蛋白所含赖氨酸和丝氨酸的量较少。据推测，所发现的这些变化可能是由软骨退变时软骨细胞对蛋白聚糖蛋白主干的非典型合成所诱导的。
