[Several indicators of histamine metabolism in hyperbaric oxygenation].

Content of histamine, activity of diamine oxidase in rat brain, liver, lung tissues and blood as well as histaminopexic effect of blood serum were studied after treatment of the animals with oxygen at 0.3 MPa within 60 and 120 min. Hyperoxia caused dissimilar alterations in content of blood and tissue histamine: the first group of animals was characterized by a distinct impairment of histamine metabolism in tissues accompanied by a high level of the amine in blood, in the second group these alterations were not found. Role of histamine in compensatory-adaptation mechanisms caused by hyperoxia as well as in pathogenesis of oxygen intoxication is discussed.