[Dynamics of the histamine content and diamine oxidase activity of the blood in patients with ischemic stroke and transient disorders of cerebral blood circulation].

Ninety-four patients with acute impairments of the cerebral circulation (AICC) were studied for the activity of diamine oxidase and histamine levels in the blood. It was found for the first time ever that the activity of diamine oxidase was reduced in the precrisis period and in the first hours of the AICC development, and showed a tendency to rise thereafter. The histamine levels were elevated already in the precrisis period and remained high throughout the acute period of cerebral circulatory impairment. The levels of histamine and activity of diamine oxidase are determined by the previous (occurring several days earlier) impairments of the cerebral circulation. Histamine and diamine oxidase play an active part in the pathogenesis of AICC which is of practical significance in the treatment of not only ischemic stroke but also of transient impairments of the cerebral circulation.