范科尼贫血患者红细胞和白细胞中超氧化物歧化酶活性降低。

Decreased superoxide dismutase activity of erythrocytes and leukocytes in Fanconi's anemia.

作者信息

Yoshimitsu K, Kobayashi Y, Usui T

出版信息

Acta Haematol. 1984;72(3):208-10. doi: 10.1159/000206389.

DOI:10.1159/000206389

Abstract

Superoxide dismutase (SOD) activity was determined in the erythrocytes and leukocytes of 5 patients with Fanconi's anemia (FA) and 1 with atypical Fanconi's anemia without any hematological disorder. SOD activity was decreased in the blood cells of the patients with Fanconi's anemia, but was normal in the atypical patient. The influence of SOD on the chromosome aberrations and hematological disorder in FA is discussed.

摘要

测定了5例范可尼贫血（FA）患者及1例无任何血液系统疾病的非典型范可尼贫血患者红细胞和白细胞中的超氧化物歧化酶（SOD）活性。范可尼贫血患者血细胞中的SOD活性降低，但非典型患者的SOD活性正常。文中讨论了SOD对范可尼贫血患者染色体畸变和血液系统疾病的影响。