双氢麦角毒碱（海得琴）与乙醇诱导C57BL/6J雄性小鼠衰老

Dihydroergotoxine(Hydergine) and ethanol-induced aging of C57BL/6J male mice.

作者信息

Samorajski T, Rolsten C, Pratte K A

出版信息

Pharmacology. 1978;16 Suppl 1:36-44. doi: 10.1159/000136807.

Abstract

The residual effects of dihydroergotoxine (Hydergine), ethanol, and Hydergine-plus-ethanol were investigated in old male mice of the C57BL/6J strain. Prolonged 10% v/v ethanol, concomitant with adequate nutrition, produced a significant decrease in life-span, decreased spontaneous locomotor activity and reduced lipofuscin accumulation in neurons of the reticularis gigantocellularis. These effects were not apparent in mice treated with Hydergine or alcohol combined with Hydergine.

摘要

在C57BL/6J品系的老年雄性小鼠中研究了双氢麦角毒碱（喜得镇）、乙醇以及双氢麦角毒碱加乙醇的残留效应。持续给予10%（v/v）乙醇并提供充足营养，会使小鼠寿命显著缩短，自发运动活性降低，巨细胞网状核神经元中的脂褐素积累减少。这些效应在接受喜得镇治疗的小鼠或乙醇与喜得镇联合治疗的小鼠中并不明显。