乙醇和双氢麦角毒碱对小鼠脑髓鞘成分的影响。
Effects of ethanol and dihydroergotoxine on mouse brain myelin components.
作者信息
Sun G Y, Creech D M, Sun A Y, Samorajski T
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):617-20.
The effects of prolonged consumption of ethanol, dihydroergotoxine (Hydergine) and Hydergine-plus-ethanol on brain myelin components isolated from the medulla oblongata of mouse brain were examined. Based on protein content, the amount of myelin isolated from the brain tissue was not different with regard to the various treatments. However, there was a significant decrease (20%) in myelin phospholipid and cholesterol to protein ratios in the ethanol group as compared to controls and the Hydergine-treated group. On the contrary, the Hydergine and Hydergine-ethanol groups had higher cholesterol to phospholipid ratios than controls. In spite of the changes in membrane components, little change in acyl group composition of the phosphoglycerides was found in myelin.
研究了长期摄入乙醇、双氢麦角毒碱（喜得镇）以及喜得镇加乙醇对从小鼠延髓分离出的脑髓鞘成分的影响。基于蛋白质含量，从脑组织中分离出的髓鞘量在不同处理组之间并无差异。然而，与对照组和喜得镇处理组相比，乙醇组的髓鞘磷脂和胆固醇与蛋白质的比率显著降低（20%）。相反，喜得镇组和喜得镇加乙醇组的胆固醇与磷脂的比率高于对照组。尽管膜成分发生了变化，但在髓鞘中甘油磷脂的酰基组成几乎没有变化。
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