纳曲酮对酗酒者酒精“快感”的影响。
Effect of naltrexone on alcohol "high" in alcoholics.
作者信息
Volpicelli J R, Watson N T, King A C, Sherman C E, O'Brien C P
机构信息
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.
出版信息
Am J Psychiatry. 1995 Apr;152(4):613-5. doi: 10.1176/ajp.152.4.613.
OBJECTIVE
Subjective effects of alcohol in alcoholics treated with naltrexone or placebo were compared.
METHOD
In a previously reported double-blind clinical trial of 50 mg/day of naltrexone or placebo for treatment of alcoholism, 36 of 70 detoxified male veterans deviated from abstinence. Of these 36, 29 subsequently reported on the subjective effects of drinking during the trial.
RESULTS
A larger proportion of naltrexone-treated subjects (seven of 12) than placebo-treated subjects (two of 17) reported that the "high" produced by alcohol during the study was significantly less than usual. The naltrexone-treated subjects also drank less alcohol than the placebo-treated subjects during the first drinking episode. There was no difference between groups in reported intoxication, craving, memory, or loss of temper.
CONCLUSIONS
The lower alcohol consumption by the naltrexone-treated subjects may have resulted from naltrexone's blockage of the pleasure produced by alcohol.
目的
比较纳曲酮或安慰剂治疗的酗酒者中酒精的主观效应。
方法
在先前报道的一项关于每天50毫克纳曲酮或安慰剂治疗酒精中毒的双盲临床试验中，70名已戒酒的男性退伍军人中有36人未戒酒。在这36人中，有29人随后报告了试验期间饮酒的主观效应。
结果
报告称研究期间酒精产生的“兴奋感”明显低于平常的纳曲酮治疗组受试者比例（12人中有7人）高于安慰剂治疗组受试者比例（17人中有2人）。在首次饮酒发作期间，纳曲酮治疗组受试者饮用的酒精量也少于安慰剂治疗组受试者。两组在报告的醉酒、渴望、记忆或发脾气方面没有差异。
结论
纳曲酮治疗组受试者饮酒量较低可能是由于纳曲酮阻断了酒精产生的愉悦感。
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