Govier A V, Reves J G, McKay R D, Karp R B, Zorn G L, Morawetz R B, Smith L R, Adams M, Freeman A M
Ann Thorac Surg. 1984 Dec;38(6):592-600. doi: 10.1016/s0003-4975(10)62316-8.
In this study we examined the relationship of regional cerebral blood flow (CBF) to mean arterial pressure, systemic blood flow, partial pressure of arterial carbon dioxide (PaCO2), nasopharyngeal temperature, and hemoglobin during hypothermic nonpulsatile cardiopulmonary bypass (CPB). Regional CBF was determined by clearance of xenon 133 in 67 patients undergoing coronary bypass grafting procedures. There was a significant decrease in regional CBF (55% decrease) during CPB, with nasopharyngeal temperature and PaCO2 being the only two significant factors (p less than 0.05). In a subgroup of 10 patients, variation of pump flow between 1.0 and 2.0 L/min/m2 did not significantly affect regional CBF. We conclude that cerebral autoregulation is retained during hypothermic CPB. Under the usual conditions of CPB, variations in flow and pressure are not associated with important physiological or detrimental clinical affects.
在本研究中，我们检测了在低温非搏动性体外循环（CPB）期间，局部脑血流量（CBF）与平均动脉压、全身血流量、动脉二氧化碳分压（PaCO2）、鼻咽温度及血红蛋白之间的关系。通过133氙清除法测定了67例行冠状动脉搭桥手术患者的局部CBF。CPB期间局部CBF显著降低（降低55%），其中鼻咽温度和PaCO2是仅有的两个显著因素（p<0.05）。在10例患者的亚组中，泵流量在1.0至2.0L/min/m2之间变化时，对局部CBF无显著影响。我们得出结论，低温CPB期间脑自动调节功能得以保留。在CPB的通常条件下，流量和压力的变化与重要的生理影响或有害的临床影响无关。
