Kreitmann P, Sabatier M, Schmitt R, Jourdan J, Dor V
Arch Mal Coeur Vaiss. 1984 Oct;77(10):1127-31.
The introduction of intracoronary thrombolysis as a treatment for myocardial infarction has led to an increase in the number of very early coronary angiographies carried out in the acute phase of myocardial infarction. These investigations can be performed without excessive risk. In some cases, severe stenosis with significant distal circulatory impairment without evidence of thrombosis is found. In these very early investigations, these findings may represent a "pre-thrombolic" lesion in an evolving myocardial infarction. Six cases of very severe pre-thrombolitic stenosis of the LAD were observed in a series of 67 coronary angiographies performed in the early stages of myocardial infarction. These six cases were selected on strict clinical, ECG and angiographic criteria. One patient was hospitalised with cardiogenic shock. The six patients underwent emergency coronary bypass surgery: average time from admission to coronary angiography was 55 minutes; average time from coronary angiography to surgery was 3 hours. These 6 pre-thrombolic lesions of the LAD were also associated with lesions of the left circumflex and right coronary arteries. There were no operative complications but two patients had stormy immediate postoperative periods. There was no hospital mortality. All patients were reinvestigated at 1 month and all grafts were shown to be patent. The left ventricular ejection fractions improved in 3 cases, remained unchanged in 2 cases, and deteriorated in 1 case (the patient with cardiogenic shock). These results suggest that emergency coronary bypass surgery is a rational treatment of pre-thrombolic coronary stenosis observed at early coronary angiography in patients with evolving myocardial infarction in order to preserve as much myocardial muscle as possible.
冠状动脉内溶栓作为心肌梗死的一种治疗方法的引入,导致在心肌梗死急性期进行的极早期冠状动脉造影数量增加。这些检查可以在没有过多风险的情况下进行。在某些情况下,发现严重狭窄伴有明显的远端循环障碍但无血栓形成证据。在这些极早期检查中,这些发现可能代表正在演变的心肌梗死中的“血栓前”病变。在一系列心肌梗死早期进行的67例冠状动脉造影中,观察到6例左前降支(LAD)极严重的血栓前狭窄。这6例是根据严格的临床、心电图和血管造影标准挑选出来的。1例患者因心源性休克入院。这6例患者均接受了急诊冠状动脉搭桥手术:从入院到冠状动脉造影的平均时间为55分钟;从冠状动脉造影到手术的平均时间为3小时。这6例LAD的血栓前病变还与左旋支和右冠状动脉病变相关。手术无并发症,但2例患者术后早期情况不稳定。无医院死亡病例。所有患者在1个月时再次接受检查,所有移植血管均显示通畅。3例患者左心室射血分数改善,2例不变,1例(心源性休克患者)恶化。这些结果表明,急诊冠状动脉搭桥手术是对心肌梗死患者早期冠状动脉造影中观察到的血栓前冠状动脉狭窄进行合理治疗的方法,以便尽可能多地保留心肌。