Tozzi M G, Sgarrella F, Barsacchi D, Ipata P L
Biochem Int. 1984 Sep;9(3):319-25.
In Bacillus cereus purine ribonucleosides and deoxyribonucleosides share a common inducible catabolic pathway, leading to the formation of ribose-5-P or deoxyribose-5-P respectively inside the cell, while the purine ring remains in the external medium. Both ribo- and deoxyribonucleosides are inducers of adenosine deaminase, inosine-guanosine phosphorylase and phosphopentomutase, the enzymes of the catabolic pathway. We now show that deoxyribonucleosides, but not ribonucleosides, induce the aldolase specific for deoxyribose-5-P (2-deoxy-D-ribose-5-phosphate acetaldehyde lyase, EC 4.1.2.4), thus allowing the sugar moiety of exogenous deoxyribonucleosides to be utilized as an energy source.
在蜡样芽孢杆菌中，嘌呤核糖核苷和脱氧核糖核苷共享一条共同的可诱导分解代谢途径，分别导致在细胞内形成5-磷酸核糖或5-磷酸脱氧核糖，而嘌呤环则保留在细胞外培养基中。核糖核苷和脱氧核糖核苷都是腺苷脱氨酶、肌苷-鸟苷磷酸化酶和磷酸戊糖变位酶（分解代谢途径的酶）的诱导剂。我们现在表明，脱氧核糖核苷而非核糖核苷可诱导对5-磷酸脱氧核糖具有特异性的醛缩酶（2-脱氧-D-核糖-5-磷酸乙醛裂解酶，EC 4.1.2.4），从而使外源脱氧核糖核苷的糖部分能够用作能源。
